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What is the role of vitamin C in iron absorption, and which meal components can inhibit iron absorption?

Vitamin C reduces iron absorption; inhibitors include citrus and iron supplements

Vitamin C enhances non-heme iron absorption; inhibitors include phytates, calcium, polyphenols, and caffeine when consumed with iron-rich meals

Vitamin C plays a crucial role in iron absorption by enhancing non-heme iron uptake in the gut. It does this by reducing ferric iron (Fe3+) to the more soluble ferrous form (Fe2+) and by forming a soluble complex that keeps iron available for absorption. This effect is especially important for non-heme iron, which is found in plant foods and fortified products; heme iron from animal sources is absorbed well on its own.

Several dietary components can inhibit iron absorption. Phytates in whole grains, legumes, and seeds bind iron and prevent its absorption. Calcium from dairy or supplements can interfere by competing for absorption. Polyphenols, such as tannins in tea and coffee, can also bind iron and reduce its uptake. Caffeine, when consumed with iron-rich meals, can further reduce absorption.

To maximize absorption, pair iron-rich plant foods with vitamin C–rich foods (like citrus, peppers, or tomatoes) and avoid consuming calcium-rich foods or tea/coffee during the same meal as iron-rich foods; if possible, separate these beverages by a couple of hours.

Vitamin C has no effect; inhibitors include water

Vitamin C destroys iron; inhibitors include iron-rich meals

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